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Publications in VIVO

Burns, Colin S. Director of Graduate Studies, Department of Chemistry


Research in the Burns lab focuses on elucidating the metal binding motifs intrinsically disordered proteins (IDPs) use and on characterizing the effect metal binding has on the overall structure and behavior of the protein.  Ultimately, the goal is to understand protein function, and possibly misfunction, on a molecular level.  The structure and function of proteins is investigated using peptide synthesis, recombinant DNA methodology, and spectroscopy.  We make extensive use of circular dichroism (CD) spectroscopy, fluorescence spectroscopy and mass spectrometry in these studies.  Additionally, we make use of magnetic resonance techniques, specifically one and two-dimensional nuclear magnetic resonance (NMR) spectroscopy and electron paramagnetic resonance (EPR) spectroscopy.  Many of proteins we plan to examine are involved in devastating neurological diseases.