- Microbiology and Immunology Associate Professor
Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8), a member of the γ2-herpesvirus family, is involved in the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma and a subset of multicentric Castleman disease.KSHV was first described in KS lesion by representational difference analysis.KSHV associated diseases occur in HIV negative as well as HIV positive patients around the world.KS is often times referred to as AIDS-defining illness.Advances in virus biology (includes both herpesviruses and others) have been made by the use of virus specific target cells and analyzing different stages of the virus infectious process, critical signaling cascades induced by the virus, and those cellular signals that benefit the virus infection. However, there is very little research performed on the effect of such cellular signals on virus entry, infection, and pathogenesis.My labs primary focus is on,
(i) Understanding the manner by which cellular proteins alter KSHV infection and mediated pathogenesis.
(ii) Understanding the manner by which cellular signaling alter the milieu in HIV infected patients critical to the development of KS.
The long term goals will be aimed at (1) understanding certain unexplained facets of the virus biology; and (2) developing anti-viral/anti-cancer therapies based on targeting specific signaling molecule(s).